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Updated: Feb 26, 2026
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Carbon-ion radiotherapy for isolated para-aortic lymph node recurrence from colorectal cancer
Yuka Isozaki1,2, Shigeru Yamada1, Shohei Kawashiro1
1Hospital of the National Institute for Quantum and Radiological Science and Technology, Chiba, Japan.
Background:
The safety and effectiveness of carbon-ion radiotherapy (CIRT) for isolated para-aortic lymph node (PALN) metastasis was evaluated retrospectively.
Methods:
CIRT for isolated PALN metastasis from CRC was performed in 34 cases from June 2006 to August 2015 in our institute. A median dose of 52.8 Gy(RBE) (range, 48-52.8 Gy(RBE)) was delivered with a median daily dose of 4.4 Gy(RBE) (range, 4.0-4.4 Gy(RBE)).
Results:
The median follow-up duration for all patients was 24.4 months (range, 7-82.8 months). There were 13 cases (38.2%) who achieved complete response after treatment. The local control rates at 2 and 3 years were 70.1% and 70.1%, respectively. The overall survival rates at 2 and 3 years were 83.3% and 63.0%, respectively. The 3-year survival rates for Stage I-III were 68.7%, while those for Stage IV was 0%. The overall survival of cases with rectal cancer or with high CA19-9 values pre-CIRT tended to be worse. The median survival period was 41.7 months. Twelve of the 34 patients survived for more than 3 years. There were no adverse effects of Grade 3 or higher.
Conclusions:
CIRT for isolated PALN recurrence after curative resection for CRC appears effective and safe, and it is considered a promising therapy.
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