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Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

[Single center retrospective study of 184 children with inflammatory bowel disease seen from 2000-2014]

D X Guan¹, F H Yu, G L Wang

¹Department of Gastroenterology, Beijing Children's Hospital, Faculty of Digestive Diseases, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing 100045, China.

Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics

|July 21, 2017

Insights

Pediatric inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is increasing. Early-onset and infantile IBD are common, with CD often presenting with perianal disease and UC involving extensive lesions.

Area of Science:

Pediatric Gastroenterology
Inflammatory Bowel Disease Research
Clinical Epidemiology

Background:

Inflammatory Bowel Disease (IBD) encompasses Crohn's disease (CD) and ulcerative colitis (UC), affecting children with significant clinical challenges.
Understanding the evolving clinical characteristics and trends of pediatric IBD is crucial for effective management and treatment strategies.

Purpose of the Study:

To retrospectively analyze clinical data of pediatric patients diagnosed with IBD (CD and UC) between 2000 and 2014.
To identify key clinical characteristics, disease trends, and changes over a 15-year period in a pediatric cohort.

Main Methods:

Retrospective analysis of hospitalized pediatric patients diagnosed with IBD at Beijing Children's Hospital from 2000 to 2014.
Data categorized by disease type (CD, UC) and admission year into distinct groups for comparative analysis.

Main Results:

A total of 184 pediatric IBD cases were analyzed, with a notable increase in hospitalization ratios for both CD and UC over the study period (P<0.05).
Early-onset IBD, including very early onset and infantile IBD, constituted a significant proportion (61.4% and 41.8% respectively).
CD commonly presented as ileocolonic type with non-structuring behavior and perianal disease (31.1%), while UC frequently involved pancolitis (59.1%). Severe UC (S3) was more prevalent in earlier years (Group A2) compared to moderate UC (S2) in later years (Group C2) (P=0.0017).

Conclusions:

The incidence of pediatric IBD requiring hospitalization shows a growing trend, with a high prevalence of early-onset and infantile cases.
CD in children is often characterized by perianal disease and moderate to severe activity, with higher rates of surgery, obstruction, and perforation compared to UC.
UC cases frequently exhibit extensive colonic lesions and higher disease activity, with a shift towards less severe disease presentations in recent years.

Read full analysis

Abstract:

Objective: To investigate the clinical data of children with inflammatory bowel disease (IBD) retrospectively, including Crohn's disease (CD) and ulcerative colitis (UC) and identify the clinical characteristics and trends of change. Method: Clinical data of hospitalized patients diagnosed as IBD in Beijing Children's Hospital from January 2000 to December 2014 were collected and retrospectively analyzed. Patients were divided into six groups based on type of disease and year of admission: Group A1(CD, 2000-2004) included 12 patients, Group B1(CD, 2005-2009) included 11, Group C1(CD, 2010-2014) included 51; Group A2(UC, 2000-2004) included 17, Group B2(UC, 2005-2009) included 25, Group C2(UC, 2010-2014) included 68. Result: A total of 184 IBD patients were included in the study, 74 had CD and 110 had UC. The hospitalization constituent ratio of CD increased from 0.6/10 000 in Year 2000 to 2.9/10 000 in Year 2014. The hospitalization constituent ratio of UC increased from 0.5/10 000 in Year 2001 to 3.9/10 000 in Year 2014. The hospitalization constituent ratios of CD and UC both increased gradually(P<0.05). Up to 61.4%(113/184) of IBD patients belong to early onset IBD, furthermore the very early onset IBD and infantile IBD accounted for 41.8%(77/184) and 26.6%(49/184) respectively. For CD, ileocolonic type(47.3%, 35/74) and non-structuring, non-penetrating type (67.6%, 50/74) were more common. Perianal disease occured in 31.1%(23/74) of CD patients; 81.1%(60/74) of CD patients had moderate/severe activity. For UC, pancolitis type(59.1%, 65/110) was more common. There were no significant changes for location of pathological change, disease behavior, activity degree of CD, extent of UC lesion and incidence of surgery, intestinal perforation and hemorrhage of gastrointestinal tract for IBD in the past 15 years(P>0.05). Severe UC(S3) was more common in Group A2(64.7%, 11/17), but moderate UC(S2) was more common in Group C2(48.5%, 33/68), the difference was statistically significant (P=0.001 7). Conclusion: During the past 15 years, the hospitalization constituent ratio for IBD in our hospital showed a growing trend. The ratio of infantile IBD and very early onset IBD was high. For CD, perianal disease was commonly seen and most patients had moderate/severe activity. The surgery rate and incidence of intestinal obstruction and perforation were higher in the CD patients than UC patients. For UC, the lesions were more extensively combined with higher disease activity.

Keywords:

Child Colitis, ulcerative Crohn disease Inflammatory bowel diseases

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