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Updated: Feb 26, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
Post-prandial decrease in plasma growth hormone levels is not related to the increase in plasma insulin levels in
Koki Nishihara1, Ryoko Kobayashi1, Yutaka Suzuki2
1Laboratory of Animal Physiology, Graduate School of Agricultural Science, Tohoku University, Sendai 980-0845, Japan.
Post-feeding increases in insulin or glucose do not lower growth hormone (GH) in ruminants. Insulin injections paradoxically increased GH and cortisol, suggesting hypoglycemia
Area of Science:
- Endocrinology
- Animal Physiology
- Ruminant Metabolism
Background:
- Post-prandial hormonal changes are crucial for nutrient utilization in ruminants.
- Growth hormone (GH) secretion is known to be influenced by metabolic status.
Purpose of the Study:
- To investigate the relationship between post-prandial insulin and growth hormone (GH) levels in ruminants.
- To determine if elevated insulin or glucose levels suppress GH after feeding.
Main Methods:
- Two experiments were conducted on male Shiba goats.
- Intravenous insulin or glucose was administered to modulate plasma insulin levels.
- Growth hormone and cortisol concentrations were measured post-injection.
Main Results:
- Insulin injection significantly increased GH and cortisol concentrations.
- Glucose injection significantly increased GH but not cortisol.
- Hypoglycemia from insulin may stimulate the adrenal cortex, influencing GH levels.
Conclusions:
- Post-prandial increases in plasma insulin or glucose do not decrease GH concentration in ruminants.
- The study suggests an indirect or complex relationship between insulin, glucose, and GH regulation in ruminants.
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