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Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Published on: May 18, 2020
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Treating breast cancer with cell-based approaches: an overview
Susanna Gallo1, Dario Sangiolo1,2, Fabrizio Carnevale Schianca1
1a Medical Oncology , Candiolo Cancer Institute-FPO (IRCCS) , Candiolo , Italy.
Expert Opinion on Biological Therapy
|July 22, 2017
Summary
Cell therapy using bone marrow and blood cells offers new hope for breast cancer treatment. Evolving from supportive care, these approaches now aim to harness immune cells for anticancer immunity, showing promise for solid tumors.
Area of Science:
- Oncology
- Immunology
- Hematology
Background:
- Breast cancer remains a leading cause of cancer death in women globally.
- Metastatic breast cancer is currently incurable, highlighting the need for novel therapeutic strategies.
- Pharmacological treatments have limitations, prompting exploration of cell-based therapies.
Purpose of the Study:
- To review the evolution and application of cell therapy in breast cancer treatment.
- To discuss stem cell transplantation and adoptive immunotherapy approaches.
- To highlight the potential of cell-based strategies against metastatic breast cancer.
Main Methods:
- Review of autologous stem cell transplantation (ASCT) for high-dose chemotherapy.
- Discussion of allogeneic stem cell transplants.
- Exploration of adoptive immunotherapy using bone marrow-derived T-cells.
Main Results:
- Cell therapy has advanced from supportive care to an active therapeutic strategy.
- Focus has shifted towards immune cell-mediated anticancer effects.
- Adoptive immunotherapies show significant potential for solid tumors, including breast cancer.
Conclusions:
- Bone marrow and peripheral blood-derived cell therapies are evolving therapeutic options for breast cancer.
- Adoptive immunotherapies, including engineered cells, are promising for treating breast cancer.
- Cell therapy represents a significant advancement in the fight against metastatic breast cancer.
Keywords:
Breast canceradoptive cell immunotherapyallogeneic transplantbone marrow transplantcancer metastasishigh-dose chemotherapyperipheral blood stem cell transplantMore Related Videos
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