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[Decrease of various enzyme activities in the amniotic fluid of the fetuses with chromosomal anomalies].

F Muller, M Rebiffé, H Der Sarkissian

    Annales De Genetique
    |January 1, 1986
    PubMed
    Summary

    Enzymatic activities of gamma-glutamyl-transpeptidase and aminopeptidase M were lower in amniotic fluid from pregnancies with trisomy. These reduced enzyme levels may indicate fetal growth retardation in trisomic pregnancies.

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    Amniotic fluid digestive enzymes: diagnostic value in fetal gastrointestinal obstructions.

    Prenatal diagnosis·1994

    Area of Science:

    • Biochemistry
    • Prenatal Diagnostics
    • Genetics

    Background:

    • Amniotic fluid contains enzymes that can reflect fetal health.
    • Trisomy, a chromosomal abnormality, can impact fetal development.
    • Gamma-glutamyl-transpeptidase and aminopeptidase M are enzymes with known biological functions.

    Purpose of the Study:

    • To investigate the enzymatic activities of gamma-glutamyl-transpeptidase and aminopeptidase M in amniotic fluid.
    • To determine if these enzyme levels differ in pregnancies with a trisomic conceptus.
    • To explore the potential link between enzyme activity and fetal growth in trisomic pregnancies.

    Main Methods:

    • Enzymatic assays were performed on amniotic fluid samples.
    • Samples were collected from pregnancies diagnosed with trisomy.

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  • Control samples from normal pregnancies were likely used for comparison (implied).

    • Main Results:

    • Lower enzymatic activities of gamma-glutamyl-transpeptidase were observed.
    • Reduced levels of aminopeptidase M were detected.
    • These low enzyme values were noted in amniotic fluids from trisomic pregnancies.

    Conclusions:

    • The observed low enzymatic activities may be associated with trisomy.
    • Fetal growth retardation is a potential consequence linked to these reduced enzyme levels.
    • Further research may be warranted to confirm the diagnostic and prognostic value of these enzymes in trisomy.