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Related Experiment Videos

Arousal and drug abuse.

Francisco J Urbano1, Verónica Bisagno1, Edgar Garcia-Rill2

  • 1IFIBYNE-CONICET, ININFA-CONICET, University of Buenos Aires, Argentina.

Behavioural Brain Research
|July 22, 2017
PubMed
Summary

The reticular activating system

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Area of Science:

  • Neuroscience
  • Neurobiology

Background:

  • The reticular activating system (RAS) comprises distinct nuclei influencing arousal states.
  • The pedunculopontine nucleus (PPN) plays a role in arousal-related electroencephalogram (EEG) activity during waking and REM sleep.

Purpose of the Study:

  • To investigate the role of arousal mechanisms in the reticular activating system (RAS) in drug abuse.
  • To examine the impact of drugs of abuse on PPN electrical coupling and gamma band activity.

Main Methods:

  • Analysis of PPN cell properties, including electrical coupling and high-threshold calcium channels.
  • Consideration of neurobiological processes underlying drug abuse, withdrawal, and relapse during wakefulness.

Main Results:

  • Recent discoveries highlight electrical coupling and beta/gamma band oscillations in PPN cells.
  • Drug abuse and relapse are linked to neurobiological processes occurring during wakefulness.

Conclusions:

  • Arousal, specifically RAS electrical coupling and gamma band activity, may be crucial in addiction and relapse.
  • Understanding these mechanisms offers potential therapeutic targets for drug abuse disorders.
Keywords:
CocaineConnexin 36DopamineModafinilN- and P/Q-type calcium channelsPreconscious awareness

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