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Update on pediatric sepsis: a review

Tatsuya Kawasaki1

  • 1Department of Pediatric Critical Care, Shizuoka Children's Hospital, 860 Ursuhiyama, Aoi-ku, Shizuoka, Shizuoka 420-8660 Japan.

Journal of Intensive Care
|July 22, 2017
PubMed

Insights

Pediatric sepsis management is advancing with new insights into hemodynamics and antimicrobials. The SPROUT study provides crucial data, improving outcomes for critically ill children with sepsis.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Epidemiology

Background:

  • Sepsis is a major global cause of child mortality.
  • Limited evidence exists for pediatric sepsis, often relying on adult data and expert consensus.
  • Recent advancements offer new perspectives on pediatric sepsis since 2012.

Purpose of the Study:

  • To update knowledge on pediatric sepsis management.
  • To highlight findings from the global SPROUT study.
  • To address the definition and outcomes of pediatric sepsis.

Main Methods:

  • Incorporation of new findings in hemodynamic management and antimicrobial timing.
  • Review of quality improvement initiatives like pediatric sepsis bundles.
  • Analysis of data from the global SPROUT epidemiological study.

Main Results:

  • Improved understanding of hemodynamic management and antimicrobial use in pediatric sepsis.
  • Demonstrated success of pediatric sepsis bundles in improving clinical outcomes.
  • The SPROUT study revealed demographics, interventions, outcomes, and challenged the current pediatric sepsis definition.

Conclusions:

  • Updated knowledge is expected to drive further progress in pediatric sepsis management.
  • The SPROUT study established foundational data for future pediatric sepsis research.
  • Re-evaluation of the pediatric sepsis definition is indicated based on new evidence.
Abstract

Keywords:
AlgorithmAntibioticsChildEpidemiologyHemodynamic managementPediatricPrognosisSepsisSeptic shockSurviving Sepsis Campaign

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