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Innovative Dietary Intervention Answers to Baby Colic
Ioannis Xinias1, A Analitis2, Antigoni Mavroudi1
13rd Pediatric Department, Hippocration Hospital, Thessaloniki, Greece.
Insights
A specialized infant formula significantly reduced crying time in colicky infants. This synbiotic, reduced-lactose formula also improved infant and parent quality of life scores.
Area of Science:
- Pediatric Nutrition
- Gastroenterology
- Microbiome Research
Background:
- Infantile colic affects numerous infants, causing significant distress to families.
- Current management strategies for colic offer limited efficacy.
- Dietary interventions are being explored to alleviate colic symptoms.
Purpose of the Study:
- To assess the effectiveness of a novel synbiotic, lactose-reduced partial whey hydrolysate formula in treating infantile colic.
- To evaluate the impact of this formula on infant crying duration and parental quality of life.
Main Methods:
- A one-month randomized controlled trial involving 40 infants with colic receiving the intervention formula and 20 controls receiving standard formula.
- Both groups received parental reassurance.
- Quality of life questionnaires were administered to parents before and after the intervention.
Main Results:
- Infants receiving the intervention formula experienced a significant reduction in crying duration (2.7 hours) compared to controls (1.2 hours).
- The intervention group showed significant improvements in all quality of life parameters, surpassing the control group's improvements.
- Stool consistency improved in the intervention group, though defecation frequency remained unchanged.
Conclusions:
- The tested partial whey hydrolysate formula, containing synbiotics and reduced lactose, effectively reduces crying time in infants with colic.
- This dietary intervention significantly enhances the quality of life for both infants and their parents.
- The findings support the use of this specialized formula as a therapeutic option for infantile colic.
Purpose:
The purpose of this paper is to evaluate the efficacy of a lactose- reduced synbiotic partial whey hydrolysate in formula fed infants presenting with colic and the impact of this dietary intervention in mean crying time and quality of life.
Methods:
Forty infants with infantile colic were treated during one month with parental reassurance and the intervention formula (partial whey hydrolysate, reduced lactose, Bifidobacterium lactis BB12 and galacto-oligosaccharides) and were compared to a control group of 20 infants with infantile colic treated with parental reassurance and a standard infant formula. Parents completed a quality of life (QoL) questionnaire assessing the burden of infantile colic. Wilcoxon test, t-test and Mann-Whitney test were used to compare QoL scores before and after intervention as well as between the intervention and control group.
Results:
At inclusion, duration of crying did not differ between both groups. Crying duration decreased with 2.7 hours (from 3.2 to 0.5 hours) in the intervention group while duration of crying decreased only with 1.2 hours in the control group (p<0.001). Stool composition became looser in the intervention group, but defecation frequency did not change. The median scores of the QoL questionnaire improved significantly in the intervention group for all parameters. In the control group, parameters improved significantly also but not for the parent-child and social interaction. The score changes were significantly greater in the intervention than in the control group.
Conclusion:
The intervention formula (partial whey hydrolysate, synbiotic, reduced lactose) significantly reduced the duration of crying and improved QoL of the parents and infants.
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