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Updated: Feb 26, 2026

Imaging Corrosion at the Metal-Paint Interface Using Time-of-Flight Secondary Ion Mass Spectrometry
Published on: May 6, 2019
TLC surface integrity affects the detection of alkali adduct ions in TLC-MALDI analysis
Yonghui Dong1,2, Ruggero Ferrazza2, Andrea Anesi2
1Biostatistics and Data Management, Research and Innovation Centre - Fondazione Edmund Mach, Via Edmund Mach, 138010, San Michele all'Adige, TN, Italy.
Abstract:
Direct coupling of thin-layer chromatography (TLC) with matrix-assisted laser desorption ionization (MALDI) mass spectrometry allows fast and detailed characterization of a large variety of analytes. The use of this technique, however, presents great challenges in semiquantitative applications because of the complex phenomena occurring at the TLC surface. In our laboratory, we recently observed that the ion intensities of several alkali adduct ions were significantly different between the top and interior layer of the TLC plate. This indicates that the integrity of the TLC surface can have an important effect on the reproducibility of TLC- MALDI analyses. Graphical Abstract MALDI imaging reveals that surface integrity affects the detection of alkali adductions in TLC-MALDI.
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