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Serologic Markers of Autism Spectrum Disorder
T V Khramova1, Anna L Kaysheva2, Y D Ivanov3
1Udmurt State University, Universitetskaya st 1, Izhevsk, Russia.
Journal of Molecular Neuroscience : MN
|July 22, 2017
Summary
Autism spectrum disorder (ASD) affects millions globally. Current diagnostic protein markers lack the required sensitivity and specificity, highlighting the need for large-scale proteomic research to find reliable serologic markers for early autism detection.
Area of Science:
- Neuroscience
- Genetics
- Biochemistry
Background:
- Autism spectrum disorder (ASD) affects approximately 67 million people worldwide, with a 14% annual increase.
- Potential causes of ASD include genetic factors, central nervous system lesions, metabolic disorders, infections, and prenatal chemical exposures.
- Existing research has not identified protein markers that meet diagnostic criteria for high sensitivity, specificity, and accuracy in ASD detection.
Purpose of the Study:
- To address the critical need for reliable diagnostic markers in autism spectrum disorder.
- To investigate the potential of proteomic research for identifying novel protein-based biomarkers for ASD.
Main Methods:
- Large-scale proteomic research.
- Analysis of serologic samples to detect protein markers associated with ASD development.
Main Results:
- Current research has not identified protein markers with sufficient diagnostic efficiency (sensitivity, specificity, accuracy) for ASD.
- The study emphasizes the relevance of large-scale proteomic investigations.
Conclusions:
- There is a significant gap in identifying effective protein markers for autism spectrum disorder diagnosis.
- Large-scale proteomic research is crucial for discovering sensitive and specific serologic markers for ASD.
- Developing accurate diagnostic tools for ASD is essential given the growing prevalence of the condition.
