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Related Experiment Video

Updated: Feb 26, 2026

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Nanoneedle-Based Sensing in Biological Systems.

Ciro Chiappini1

  • 1Centre for Craniofacial and Regenerative Biology, King's College London , SE1 9RT, London, United Kingdom.

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|July 22, 2017
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Summary
This summary is machine-generated.

Nanoneedles offer a unique way to monitor cells with minimal disruption. These nanostructures enable long-term, high-resolution sensing of biological functions in various systems.

Keywords:
biointerfacebiomarkersintracellular sensinglabel-freeminimally invasivenanoneedlesnanowiresreview

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Cellular Biology

Background:

  • Nanoneedles are high aspect ratio nanostructures with a unique biointerface.
  • Their interaction with cells is peculiar yet poorly understood.
  • They offer effective sensing of intracellular conditions with lower toxicity and perturbation than traditional probes.

Purpose of the Study:

  • To review devices, strategies, and workflows for nanoneedle-based sensing in biological systems.
  • To highlight the capabilities of nanoneedles for monitoring cellular functions.
  • To explore the potential of nanoneedles in diverse biological applications.

Main Methods:

  • Long-term, reversible interfacing of nanoneedles with cells.
  • Assembly of nanoneedles into large-scale, ordered, dense arrays.
  • Utilizing nanoneedles for intracellular and extracellular sensing.

Main Results:

  • Nanoneedles enable monitoring of biological functions over several days.
  • They provide functional maps of large cell populations with submicron spatial resolution.
  • Nanoneedles can sense intracellular electrical activity, biomolecule concentration, function, and interactions.
  • Extracellularly, they measure cell-exerted forces and sort rare cells.

Conclusions:

  • Nanoneedles are versatile tools for investigating biological systems from cells to organisms.
  • Their unique properties facilitate advanced cellular monitoring and analysis.
  • Further development of nanoneedle technology promises significant advancements in biosensing.