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Intercontinental validation of brain volume measurements using MSmetrix.

Alessandro Finkelsztejn1, Yara Dadalti Fragoso2, Eder Amaral Bastos3

  • 11 Department of Neurology, Hospital de Clinicas de Porto Alegre, Brazil.

The Neuroradiology Journal
|July 22, 2017
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Summary

MSmetrix brain volume assessment software is validated for use across diverse populations. Studies show Brazilian subjects align with MSmetrix standards, confirming its global applicability in multiple sclerosis research.

Keywords:
Multiple sclerosisbrain atrophybrain volumemagnetic resonance image

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Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Brain volume assessment is critical in multiple sclerosis (MS) research and treatment.
  • MSmetrix software was developed for MS patients, using a primarily European reference population.
  • This study addresses potential population-specific variations in brain volume metrics.

Purpose of the Study:

  • To evaluate the performance of MSmetrix software with a Brazilian population.
  • To determine if MSmetrix brain volume data is applicable to non-European individuals.
  • To validate MSmetrix for broader international use in multiple sclerosis diagnostics.

Main Methods:

  • Analysis of 295 normal magnetic resonance imaging (MRI) scans from Brazilian subjects.
  • Comparison of Brazilian brain volume data against established MSmetrix standards.
  • Statistical plotting of whole brain and grey matter volumes.

Main Results:

  • Only 2% of healthy Brazilian adults fell below the 5th percentile for whole brain volume in MSmetrix.
  • A similar finding was observed for grey matter volume, with 3% below the 5th percentile.
  • These results indicate a high degree of concordance between Brazilian data and MSmetrix standards.

Conclusions:

  • MSmetrix software demonstrates applicability across different populations, including Brazilians.
  • The findings support the use of MSmetrix as a reliable tool for brain volume assessment in global MS research.
  • Population-specific calibration may not be necessary for MSmetrix software.