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Oral beta 2-selective adrenergic bronchodilators.

V Grassi, S Daniotti, M Schiassi

    International Journal of Clinical Pharmacology Research
    |January 1, 1986
    PubMed
    Summary
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    Oral beta 2-agonists are effective bronchodilators, especially for severe obstructive airways diseases. Long-term clenbuterol use is safe and effective, with mild tachyphylaxis observed in patients.

    Area of Science:

    • Pharmacology
    • Pulmonology
    • Clinical Therapeutics

    Background:

    • Oral beta 2-agonists are widely used bronchodilators with advantages like ease of use and precise dosing.
    • The oral route presents disadvantages such as delayed onset and increased side effects, but is indicated for specific patient groups.
    • Recent beta 2-agonists offer prolonged bronchodilation, necessitating post-marketing surveillance for efficacy and safety.

    Purpose of the Study:

    • To evaluate the long-term efficacy and safety of oral clenbuterol through post-marketing surveillance.
    • To investigate the phenomenon of tachyphylaxis (diminished responsiveness) during chronic beta 2-agonist treatment.
    • To assess the clinical significance of tachyphylaxis by examining various biological markers.

    Main Methods:

    Related Experiment Videos

  • Post-marketing surveillance study of oral clenbuterol in a large patient population.
  • Functional assessment of target organs and cellular beta-receptors.
  • Biochemical-metabolical indices and serum levels of cyclic nucleotides (cyclic adenosine and guanosine monophosphates) were analyzed.

    • Main Results:

    • Long-term treatment with oral clenbuterol demonstrated effectiveness and safety.
    • Tachyphylaxis was observed during long-term treatment, indicating a diminished drug response.
    • Analysis of biological markers suggested that the clinical impact of tachyphylaxis is mild.

    Conclusions:

    • Oral clenbuterol is a safe and effective therapeutic option for selected patients with chronic airways obstruction.
    • Chronic therapy with beta 2-agonists, including clenbuterol, is generally safe and effective.
    • The clinical significance of tachyphylaxis in long-term oral beta 2-agonist use appears to be minimal.