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Computerized Planning of Prostate Cryosurgery and Shape Considerations.

Purva Joshi¹, Anjali Sehrawat¹, Yoed Rabin¹

¹Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.

Technology in Cancer Research & Treatment

|July 22, 2017

Summary

This study reveals that prostate shape impacts cryosurgery planning difficulty. Optimal cryoprobe placement, especially for spherical prostates, minimizes treatment defects, potentially improving cryosurgery training.

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Area of Science:

Urology
Computational Biology
Medical Physics

Background:

Cryosurgery is a minimally invasive treatment for prostate cancer.
Computer-based planning aims to optimize cryosurgery outcomes.
Prostate geometry variability presents challenges for treatment planning.

Purpose of the Study:

To investigate the relationship between prostate shape and the complexity of computer-based cryosurgery planning.
To identify factors influencing the overall defect volume in prostate cryosurgery.
To develop strategies for improving cryosurgery planning and training.

Main Methods:

Utilized a computerized planner prototype for cryosurgery training.
Quantified planning quality using overall defect volume (undercooled/overcooled areas).

Keywords:

bioheat cryosurgery geometric modeling planning prostate simulation

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Analyzed the impact of cryoprobe number, prostate geometry, and urethral position on defect volume.

Main Results:

Overall defect volume decreased with more cryoprobes, irrespective of prostate geometry.
Symmetric and spherical prostate models, along with centrally located urethras, resulted in smaller defects.
A cryoprobe convex hull, contracted by 7-9 mm, served as an effective initial planning condition.

Conclusions:

Prostate shape significantly influences cryosurgery planning and defect volume.
A defined cryoprobe convex hull can optimize initial probe placement, accelerating planning.
This approach can enhance both computer-based planning and traditional cryosurgery training.