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Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
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Association between Cholesterol Exposure and Neuropathological Findings: The ACT Study.

Brianne M Bettcher1, M Colin Ard2, Bruce R Reed3

  • 1Departments of Neurosurgery and Neurology, Rocky Mountain Alzheimer's Disease Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Journal of Alzheimer'S Disease : JAD
|July 22, 2017
PubMed
Summary
This summary is machine-generated.

Late life non-HDL cholesterol levels were associated with Lewy body disease in older adults. This study found no links between cholesterol exposure and Alzheimer's disease or vascular brain injuries.

Keywords:
Alzheimer’s diseaseLewy bodyepidemiologylipidsneuropathologyvascular

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Area of Science:

  • Neurology
  • Gerontology
  • Cardiovascular Health

Background:

  • Cholesterol's role in aging brain health is complex.
  • Understanding late-life cholesterol's impact on neurodegeneration is crucial for preventative strategies.

Purpose of the Study:

  • To investigate the association between late-life cholesterol exposure and specific neuropathological outcomes.
  • To examine relationships with Alzheimer's disease, cerebral amyloid angiopathy, vascular brain injury, and Lewy body disease.

Main Methods:

  • Utilized data from the Adult Changes in Thought (ACT) cohort study.
  • Analyzed late-life HDL and total cholesterol levels, calculating non-HDL cholesterol.
  • Employed linear mixed models and logistic regression, controlling for relevant covariates.

Main Results:

  • No significant associations were found between late-life cholesterol and Alzheimer's disease neuropathology, amyloid angiopathy, or vascular brain injury.
  • An association was observed between predicted non-HDL cholesterol at age 70 and Lewy body disease.
  • No associations were found with Braak stage or CERAD score.

Conclusions:

  • Late-life non-HDL cholesterol exposure may be associated with Lewy body disease.
  • Further research is needed to elucidate the specific mechanisms linking cholesterol metabolism and Lewy body disease.