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MiR-155/miR-150 network regulates progression through the disease phases of chronic lymphocytic leukemia

K Vargova1, M Pesta2, P Obrtlikova3

  • 1Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Blood Cancer Journal
|July 22, 2017
PubMed
Abstract

No abstract available in PubMed .

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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