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Beta blockers and renal function: a reappraisal.

M Epstein, J R Oster

Journal of Clinical Hypertension

|March 1, 1985

Summary

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Beta blockers affect kidney function differently. Some, like propranolol, reduce renal plasma flow and filtration, while others, such as nadolol and labetalol, preserve these functions.

Area of Science:

Pharmacology
Nephrology
Cardiology

Background:

Chronic propranolol use is linked to 10%-20% reductions in renal plasma flow (RPF) and glomerular filtration rate (GFR).
Various beta-adrenergic inhibitors exhibit differing effects on renal function, prompting investigation into underlying mechanisms.

Purpose of the Study:

To explore the reasons behind the varied impact of different beta blockers on renal hemodynamics.
To understand the pathophysiological mechanisms contributing to these renal changes.

Main Methods:

Review of existing investigations on beta blocker effects on renal function.
Analysis of potential mechanisms including cardiac output, renal vascular resistance, and vasodilator inhibition.

Main Results:

Related Experiment Videos

Nadolol, ISA-positive agents, and labetalol appear to preserve renal function, unlike propranolol.
The disparity in effects may stem from multifactorial mechanisms, varying by agent.

Conclusions:

The clinical significance of beta-blocker-induced renal changes is currently unknown but likely minimal in patients with normal renal function.
Beta-adrenoceptor blockers can be used in patients with renal insufficiency, with a preference for agents that spare RPF and GFR.