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The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases

Joshua M Thurman1, Ashley Frazer-Abel1, V Michael Holers1

  • 1University of Colorado Denver, Aurora.

Arthritis & Rheumatology (Hoboken, N.J.)
|July 22, 2017
PubMed

Insights

The complement system is crucial in autoimmune diseases, driving new drug development. This review details complement activation, its role in diseases like lupus, and therapeutic strategies.

Area of Science:

  • Immunology
  • Pathogenesis of autoimmune diseases

Background:

  • The complement system plays a significant role in inflammatory and autoimmune diseases.
  • Commercial efforts are expanding to develop novel complement inhibitors and pathway-modulating drugs.

Purpose of the Study:

  • To review the evolving understanding of complement system components and activation pathways.
  • To discuss complement dysregulation in target tissues and its role in various diseases.
  • To outline approved and developing complement therapeutics for rheumatic and non-rheumatic diseases.

Main Methods:

  • Review of scientific literature on complement system biology and therapeutics.
  • Analysis of complement activation mechanisms in specific diseases (rheumatoid arthritis, lupus, thrombotic microangiopathies).
  • Discussion of therapeutic strategies and biomarker studies for complement assessment.

Main Results:

  • The complement system's central role in disease pathogenesis is increasingly recognized.
  • Successful development of complement therapeutics highlights its importance.
  • Specific mechanisms of complement activation are detailed for key diseases.

Conclusions:

  • Understanding complement pathways is vital for developing effective treatments for autoimmune and inflammatory conditions.
  • Complement therapeutics offer promising treatment options for a range of diseases.
  • Biomarker studies are essential for personalized assessment of complement system function.

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