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Put Your Mark Where Your Damage Is: Acetyl-CoA Production by ACLY Promotes DNA Repair
Samantha J Linder1, Raul Mostoslavsky2
1Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; The Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA; Massachusetts General Hospital Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA.
Abstract:
In this issue of Molecular Cell, Sivanand et al. (2017) describe the importance for nuclear ACLY-mediated production of acetyl-CoA, which promotes histone acetylation, BRCA1 recruitment, and subsequent HR-mediated DNA repair in response to DNA damage, thus drawing a direct link between DNA repair and cellular metabolism.
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