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Sodium deprivation increases the antinociceptive activity of morphine
The Journal of Pharmacy and Pharmacology
|June 1, 1986
Abstract:
In rats maintained for 50 days on a low-sodium diet and with a compensatory hyperactivity of the renin-angiotensin system, the antinociceptive activity of morphine was significantly longer-lasting than in controls. It is suggested that the renin-angiotensin system modulates opioid system responsivity.
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