Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Psoriasis and alpha-interferon.

J R Quesada, J U Gutterman

    Lancet (London, England)
    |June 28, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Recombinant-DNA-derived alpha-interferon (rIFN alpha) treatment exacerbated psoriasis in two metastatic renal carcinoma patients and caused new onset in another. This suggests interferons may play a role in psoriasis development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase.

    Cell death and differentiation·2007
    Same author

    Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model.

    Proceedings of the National Academy of Sciences of the United States of America·2001
    Same author

    Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-kappaB by inhibiting both its nuclear localization and ability to bind DNA.

    Proceedings of the National Academy of Sciences of the United States of America·2001
    Same author

    Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis.

    Cancer research·2001
    Same author

    Phase I trial of the angiogenesis inhibitor TNP-470 for progressive androgen-independent prostate cancer.

    Clinical cancer research : an official journal of the American Association for Cancer Research·2001
    Same author

    Avicins: triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation.

    Proceedings of the National Academy of Sciences of the United States of America·2001
    Same journal

    Assisted dying and the silencing of medicine's next generation.

    Lancet (London, England)·2026
    Same journal

    Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

    Lancet (London, England)·2026
    Same journal

    Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

    Lancet (London, England)·2026
    Same journal

    [<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

    Lancet (London, England)·2026
    Same journal

    Research priorities for characterising Bundibugyo virus.

    Lancet (London, England)·2026
    Same journal

    Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

    Lancet (London, England)·2026
    See all related articles

    Area of Science:

    • Immunology
    • Dermatology
    • Oncology

    Background:

    • Metastatic renal carcinoma is a serious cancer.
    • Alpha-interferon (rIFN alpha) is a biologic therapy used in cancer treatment.
    • Psoriasis is a chronic autoimmune skin condition.

    Observation:

    • Two patients with metastatic renal carcinoma experienced worsening of existing psoriasis during treatment with rIFN alpha.
    • A third patient developed new-onset psoriasis while undergoing rIFN alpha therapy.

    Findings:

    • Interferon therapy, specifically rIFN alpha, was associated with both exacerbation and onset of psoriasis.
    • These observations suggest a potential link between interferons and the pathophysiology of psoriasis.

    Implications:

    Related Experiment Videos

    • Interferons may be involved in the mechanisms underlying psoriasis.
    • Further research is warranted to explore the relationship between interferon therapy and psoriasis development.
    • This finding could inform treatment strategies for cancer patients with or at risk for psoriasis.