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Correction: Marchetti et al. MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles. <i>Int. J. Mol. Sci</i>. 2020, <i>21</i>, 1733.

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A gene network regulated by FGF signalling during ear development.

Maryam Anwar1,2, Monica Tambalo1,3, Ramya Ranganathan1

  • 1Department of Craniofacial Development & Stem Cell Biology, King's College London, London, SE1 9RT, UK.

Scientific Reports
|July 23, 2017
PubMed
Summary
This summary is machine-generated.

Fibroblast growth factor (FGF) signaling initiates inner ear development by activating a core gene circuit. This circuit stabilizes progenitor cells and later uses repressors to guide them toward mature otic cells, preventing alternative fates.

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Area of Science:

  • Developmental biology
  • Genetics
  • Molecular biology

Background:

  • Cell fate decisions during development rely on inductive signals.
  • Transcriptional circuits maintaining cell identity under changing signals are not well understood.
  • Fibroblast growth factor (FGF) signaling initiates inner ear progenitor specification.

Purpose of the Study:

  • To elucidate the genetic hierarchy downstream of FGF signaling in inner ear development.
  • To understand the transcriptional regulatory logic governing otic progenitor identity and differentiation.

Main Methods:

  • Systematic analysis of inner ear factors.
  • Network inference approach to model gene interactions.
  • Computational prediction of regulatory pathways.

Main Results:

  • FGF signaling rapidly activates a core circuit of transcription factors.
  • Positive feedback loops within this circuit stabilize otic progenitor identity.
  • A predictive network indicates subsequent roles for transcriptional repressors in differentiation and fate repression.

Conclusions:

  • Revealed the regulatory logic initiating inner ear formation.
  • Highlighted the hierarchical organization of the otic gene network.
  • Demonstrated how transcriptional circuits maintain cell identity during signaling changes.