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Updated: Feb 26, 2026

The Resident-intruder Paradigm: A Standardized Test for Aggression, Violence and Social Stress
Published on: July 4, 2013
Melatonin increases reactive aggression in humans
Jinting Liu1,2,3, Ru Zhong3, Wei Xiong3
1Shenzhen Key Laboratory of Affective and Social Cognitive Science, Shenzhen University, Shenzhen, 518060, China.
Melatonin supplementation increased reactive aggression in men, as evidenced by their selection of higher punishments in a laboratory setting. This finding highlights melatonin
Area of Science:
- Neuroendocrinology
- Social Psychology
- Behavioral Science
Background:
- Melatonin, a pineal gland hormone, regulates circadian rhythms and aging.
- Animal studies suggest melatonin influences aggression.
Purpose of the Study:
- To investigate the effect of melatonin on human aggression.
- To determine if melatonin administration impacts social behavior.
Main Methods:
- A double-blind, randomized, placebo-controlled study.
- 63 healthy males received oral melatonin or placebo.
- Participants completed the Taylor Aggression Paradigm (TAP).
Main Results:
- Melatonin group administered higher punishments more frequently than placebo.
- Increased reactive aggression persisted after controlling for confounding factors.
- Factors controlled included inhibitory ability, trait aggression, impulsiveness, and sleepiness.
Conclusions:
- Melatonin directly influences human reactive aggression.
- Provides evidence for melatonin's role in human social processes.
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