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Influenza: A Global Perspective

Elizabeth T Rotrosen1, Kathleen M Neuzil1

  • 1Center for Vaccine Development, University of Maryland, School of Medicine, 685 West Baltimore Street, Room 480, Baltimore, MD 21201, USA.

Pediatric Clinics of North America
|July 24, 2017
PubMed

Insights

Influenza vaccines are safe and effective for children, but their performance varies annually. Ongoing research aims to understand reduced effectiveness of some vaccines and improve global vaccination strategies.

Area of Science:

  • Pediatrics
  • Immunology
  • Public Health

Background:

  • Influenza poses a significant annual health risk to children, causing considerable illness and death.
  • Approved inactivated and live influenza vaccines offer protection but exhibit variable effectiveness.
  • Challenges in vaccination programs exist, particularly in tropical and subtropical regions.

Purpose of the Study:

  • To summarize the current understanding of influenza in children.
  • To highlight the role and limitations of current influenza vaccines.
  • To discuss challenges and adjuncts in pediatric influenza control.

Main Methods:

  • Review of existing literature on pediatric influenza.
  • Analysis of influenza vaccine efficacy and performance data.
  • Examination of global vaccination program logistics.

Main Results:

  • Influenza vaccines are generally safe and effective in children, though yearly effectiveness varies.
  • Recent reduced performance of live-attenuated influenza vaccines requires further investigation.
  • Logistical and feasibility issues impede vaccination programs in tropical/subtropical areas.

Conclusions:

  • Influenza vaccines remain critical for pediatric protection, necessitating ongoing research into effectiveness.
  • Antiviral medications serve as a vital supplement to vaccination strategies for prevention and treatment.
  • Addressing global disparities in vaccination programs is essential for comprehensive influenza control.

Keywords:
Antiviral medicationsChildrenInfluenzaInfluenza vaccinesVaccine policy

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