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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
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Asthma-IV: Diagnostic and Management01:30

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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Comorbidities in Difficult-to-Control Asthma.

Pieter-Paul Hekking1, Marijke Amelink1, Reinier R Wener1

  • 1Department of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.

The Journal of Allergy and Clinical Immunology. in Practice
|July 24, 2017
PubMed
Summary
This summary is machine-generated.

Difficult-to-control asthma is frequently linked to multiple comorbidities, especially in older women, former smokers, and those dependent on prednisone. Identifying these patient characteristics aids in diagnosis and prevention.

Keywords:
AsthmaComorbidityDifficult-to-control asthmaPrevalenceUncontrolled asthma

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Area of Science:

  • Pulmonology
  • Internal Medicine
  • Epidemiology

Background:

  • Difficult-to-control asthma presents a substantial medical and financial burden.
  • Comorbidities significantly contribute to uncontrolled asthma, necessitating better understanding for optimized treatment.
  • Investigating comorbidities in difficult-to-control asthma can reduce patient disease burden.

Purpose of the Study:

  • To compare the prevalence, number, and types of comorbidities in difficult-to-control asthma versus not-difficult-to-control asthma.
  • To identify patient characteristics associated with specific comorbidities in difficult-to-control asthma.

Main Methods:

  • Utilized data from 65 Dutch pharmacy databases, including 2,312 patients with asthma (914 difficult-to-control).
  • Assessed comorbidities (e.g., GERD, nasal polyps, cardiovascular disease, anxiety/depression, obesity, diabetes) via prescriptions and questionnaires.
  • Employed multivariable logistic regression to analyze associations between patient characteristics and comorbidities.

Main Results:

  • 92% of difficult-to-control asthma patients had at least one comorbidity.
  • Patients with difficult-to-control asthma had more comorbidities (2.22 vs 1.69) and higher prevalence of most, excluding diabetes and nasal polyposis.
  • Comorbidities were linked to older age, female gender, smoking history, and chronic prednisone use.

Conclusions:

  • Nearly all difficult-to-control asthma patients have comorbidities.
  • Specific patient profiles (older women, former smokers, prednisone-dependent) are associated with particular comorbidities.
  • Recognizing these characteristics can guide physician diagnostics and preventive strategies for better asthma management.