Brucellosis Causes Alteration in Trace Elements and Oxidative Stress Factors

Area of Science:

• Biochemistry
• Human Physiology
• Infectious Diseases

Background:

• Brucellosis is a widespread zoonotic disease affecting both humans and livestock.
• Trace elements play crucial roles in physiological functions and immune response.
• Oxidative stress is implicated in various inflammatory and infectious conditions.

Purpose of the Study:

• To investigate the impact of brucellosis on serum levels of key trace elements: copper (Cu), manganese (Mn), zinc (Zn), and magnesium (Mg).
• To assess the oxidative stress status in patients diagnosed with brucellosis.
• To correlate these biochemical changes with the presence of brucellosis.

Main Methods:

• A case-control study involving 40 brucellosis patients and 20 healthy controls.
• Measurement of serum copper, manganese, zinc, and magnesium levels using established laboratory techniques.
• Assessment of oxidative stress markers, including total antioxidant capacity (TAC) and malondialdehyde (MDA) levels.

Main Results:

• Serum copper levels were significantly elevated in brucellosis patients compared to controls.
• Serum zinc levels were significantly decreased in brucellosis patients.
• Total antioxidant capacity was significantly lower, and malondialdehyde levels were significantly higher in patients, indicating increased oxidative stress.

Conclusions:

• Brucellosis leads to significant alterations in the serum concentrations of essential trace elements, notably copper and zinc.
• The findings demonstrate that brucellosis induces a state of oxidative stress in affected individuals.
• These biochemical changes highlight potential mechanisms and consequences of brucellosis infection.