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Updated: Feb 26, 2026
Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Measurement of Oncometabolites D-2-Hydroxyglutaric Acid and L-2-Hydroxyglutaric Acid
Patricia M Jones1,2, Richard Boriack2, Eduard A Struys3
1Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Abstract:
We describe a liquid chromatography-tandem mass spectrometry assay for measurement of D-2-hydroxyglutaric acid and L-2-hydroxyglutaric acid. These metabolites are increased in specific inborn errors of metabolism and are now recognized as oncometabolites. The measurement of D-2-hydroxyglutarate in peripheral blood may be used as a biomarker for screening and follow-up of patients with IDH-mutated acute myeloid leukemia.
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