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Secondary Lymphoid Organs01:15

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Cutaneous Angiolymphoid Hyperplasia in a Dog.

M Michishita1, Y Katori1, H Sasaki1

  • 1Department of Veterinary Pathology, School of Veterinary Medicine, Japan.

Journal of Comparative Pathology
|July 25, 2017
PubMed
Summary

A novel canine skin condition, cutaneous angiolymphoid hyperplasia, was identified in a miniature dachshund. This rare disorder involves proliferating vascular cells and lymphoid tissue, presenting as a dermal nodule.

Keywords:
angiolymphoid hyperplasiaimmunohistochemistryskinvascular endothelial cells

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Area of Science:

  • Veterinary Pathology
  • Canine Dermatology
  • Neoplastic and Non-neoplastic Disorders

Background:

  • Dermal nodules in dogs can represent various conditions, necessitating accurate diagnosis.
  • Understanding the cellular composition of canine skin masses is crucial for effective treatment and prognosis.

Observation:

  • A 5-year-old miniature dachshund presented with a rapidly growing, firm, pale pink dermal nodule on its forelimb.
  • Histopathological examination revealed plump endothelial cells and a predominant lymphocytic infiltrate, often forming lymphoid follicles with germinal centers.

Findings:

  • Immunohistochemistry confirmed endothelial cell markers (vimentin, factor VIII-related antigen, CD31) and smooth muscle actin in surrounding cells.
  • Lymphocytes expressed CD3 or BLA36, supporting a diagnosis of canine cutaneous angiolymphoid hyperplasia.

Implications:

  • This case represents the first documented instance of canine cutaneous angiolymphoid hyperplasia, characterized by a unique combination of vascular and lymphoid proliferation.
  • This finding expands the differential diagnosis for dermal proliferative disorders in dogs.
  • Further research may elucidate the pathogenesis and optimal management strategies for this condition.