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Cutaneous Angiolymphoid Hyperplasia in a Dog.
M Michishita1, Y Katori1, H Sasaki1
1Department of Veterinary Pathology, School of Veterinary Medicine, Japan.
Journal of Comparative Pathology
|July 25, 2017
Summary
A novel canine skin condition, cutaneous angiolymphoid hyperplasia, was identified in a miniature dachshund. This rare disorder involves proliferating vascular cells and lymphoid tissue, presenting as a dermal nodule.
Area of Science:
- Veterinary Pathology
- Canine Dermatology
- Neoplastic and Non-neoplastic Disorders
Background:
- Dermal nodules in dogs can represent various conditions, necessitating accurate diagnosis.
- Understanding the cellular composition of canine skin masses is crucial for effective treatment and prognosis.
Observation:
- A 5-year-old miniature dachshund presented with a rapidly growing, firm, pale pink dermal nodule on its forelimb.
- Histopathological examination revealed plump endothelial cells and a predominant lymphocytic infiltrate, often forming lymphoid follicles with germinal centers.
Findings:
- Immunohistochemistry confirmed endothelial cell markers (vimentin, factor VIII-related antigen, CD31) and smooth muscle actin in surrounding cells.
- Lymphocytes expressed CD3 or BLA36, supporting a diagnosis of canine cutaneous angiolymphoid hyperplasia.
Implications:
- This case represents the first documented instance of canine cutaneous angiolymphoid hyperplasia, characterized by a unique combination of vascular and lymphoid proliferation.
- This finding expands the differential diagnosis for dermal proliferative disorders in dogs.
- Further research may elucidate the pathogenesis and optimal management strategies for this condition.
