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Selenium accelerates chicken dendritic cells differentiation and affects selenoproteins expression.
Zhepeng Sun1, Ci Liu1, Tingru Pan1
1College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
Developmental and Comparative Immunology
|July 25, 2017
Summary
Selenium (Se) enhances chicken dendritic cell (DC) maturation and immune response. Se supplementation boosts DC surface marker expression, indicating accelerated differentiation and improved immune function.
Area of Science:
- Poultry immunology
- Cell biology
- Nutritional science
Background:
- Selenium (Se) is vital for immune function.
- Dendritic cells (DCs) are key antigen-presenting cells.
- The effect of Se on chicken DCs was previously unknown.
Purpose of the Study:
- To investigate the impact of Selenium on chicken dendritic cell differentiation and maturation.
- To identify specific selenoproteins involved in this process.
Main Methods:
- Chicken peripheral blood mononuclear cells were cultured for 9 days.
- Recombinant chicken granulocyte-macrophage colony-stimulating factor and interleukin-4 were used for DC induction.
- Sodium selenite was added to the culture medium in the +Se group.
Main Results:
- Selenium supplementation accelerated DC differentiation.
- Increased expression of DC surface markers (CD11c, CD40, CD86, MHC II) was observed with Se.
- Selenoproteins (SelW, SelK, Dio3, GPX1, GPX2, SelN, SelS, SelH) showed high correlation in chicken DCs, with SelW strongly linked to MHC II and CD11c.
Conclusions:
- Selenium accelerates the differentiation and maturation of chicken dendritic cells.
- Selenium regulates chicken DC development through selenoproteins.
- Selenoproteins are closely correlated with the surface markers of chicken DCs.
