Drug effects on serine metabolism in psychiatric patients

The question of whether neuroleptics can play a role in the hyperserinemia and low serine hydroxymethyltransferase (SHMT) activity previously reported in psychotic patients is investigated in this report. We find that in drug-free psychotics who had significantly higher plasma serine levels (PSL) and lower SHMT activity compared to nonpsychotics and normal subjects, more than 2 weeks of neuroleptic treatment decreased PSL and did not affect SHMT activity. This finding makes it unlikely that neuroleptics play an important role in the hyperserinemia of psychotics. The possible role of dietary factors in these patients is also discussed.