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Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

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Published on: February 22, 2015

Neonatal solid tumors.

Aravindan Chandrasekaran¹

¹Meenakshi Mission Hospital and Research Centre, Madurai, India.

Pediatrics and Neonatology

|July 25, 2017

Summary

This summary is machine-generated.

Neonatal tumors are distinct from those in older children due to immature physiology. Early diagnosis and tailored treatment are crucial for managing these rare childhood cancers.

Keywords:

antenatal diagnosis of neonatal tumors congenital tumors neonatal malignant tumors neonatal tumors

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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

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Published on: September 20, 2016

Area of Science:

Pediatric Oncology
Neonatal Medicine
Tumor Biology

Background:

Neonatal tumors differ significantly from adult or older pediatric tumors.
Neonates possess immature physiological, hematopoietic, and immune systems, leading to unpredictable therapeutic responses.
Neonatal tumors necessitate distinct study and management strategies, separate from those for older children.

Purpose of the Study:

To analyze the incidence, clinical features, and management of neonatal tumors.
To highlight the unique characteristics of tumors diagnosed within the first month of life.
To emphasize the need for specialized approaches in treating neonatal malignancies.

Main Methods:

Retrospective analysis of all infants admitted with tumors between January 2011 and January 2016.
Inclusion of tumor-like conditions such as hemangiomas, lymphangiomas, and hamartomas.
Study of patient demographics, tumor types, and treatment modalities.

Main Results:

A total of 51 cases were registered, including 29 hemangiomas and lymphangiomas.
Other diagnoses comprised benign ovarian cysts (5), neuroblastomas (3), congenital fibrosarcomas (3), and sacrococcygeal teratomas (3).
Wilms' tumor, congenital mesoblastic nephroma, and hepatic hemangioendothelioma were among the rarer diagnoses.

Conclusions:

Neonatal tumors represent a distinct subset of pediatric tumors requiring specialized treatment selection.
Early diagnosis and prompt management are key to successful outcomes for most solid neonatal tumors.
Understanding the unique etiopathogenesis, behavior, and therapeutic responses is vital for improving long-term outcomes in neonates.