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Updated: Feb 26, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
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Immune checkpoint therapy of mesothelioma: Pre-clinical bases and clinical evidences

Luana Calabrò1, Giovanni Luca Ceresoli2, Armida D'Incecco1

  • 1Medical Oncology and Immunotherapy, Center for Immuno-Oncology, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy.

Cytokine & Growth Factor Reviews
|July 25, 2017
PubMed

Insights

Immune-checkpoint blocking monoclonal antibodies (mAbs) show promise for treating various cancers. This discussion explores their potential impact on malignant mesothelioma (MM), a disease with limited treatment options beyond chemotherapy.

Area of Science:

  • Oncology
  • Immunotherapy

Background:

  • Malignant mesothelioma (MM) is a rare and aggressive cancer with poor prognosis.
  • Current standard treatment relies on platinum-based chemotherapy with limited efficacy.

Purpose of the Study:

  • To review the emerging role of immune-checkpoint blocking monoclonal antibodies (mAbs) in MM treatment.
  • To highlight the potential of immunotherapy to overcome limitations of traditional chemotherapy.

Main Methods:

  • Literature review of preclinical and clinical studies on immune-checkpoint inhibitors in MM.
  • Analysis of mechanisms of action and potential biomarkers for response.

Main Results:

  • Immune-checkpoint blockade demonstrates promising efficacy in various tumor types.
  • Early data suggests potential for mAbs in MM, offering a novel therapeutic strategy.

Conclusions:

  • Immune-checkpoint blocking mAbs represent a significant advancement in cancer therapy.
  • Further research is warranted to establish the role of immunotherapy in malignant mesothelioma management.
Keywords:
CTLA-4Immune-checkpointImmunotherapyMesotheliomaPD-1PD-L1

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