Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alternative RNA Splicing02:18

Alternative RNA Splicing

25.4K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
25.4K
Alternative RNA Splicing02:18

Alternative RNA Splicing

5.3K
5.3K
RNA Splicing01:32

RNA Splicing

60.9K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.9K
What is Gene Expression?01:36

What is Gene Expression?

11.8K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
11.8K
What is Gene Expression?01:42

What is Gene Expression?

197.7K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
197.7K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

8.3K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gene synthesis from a non-coding RNA.

Nature reviews. Genetics·2024
Same author

Charting the evolutionary history of malaria.

Nature reviews. Genetics·2024
Same author

A digital marker for coronary artery disease.

Nature reviews. Genetics·2024
Same author

Global genomic diversity for All of Us.

Nature reviews. Genetics·2024
Same author

Maverick - top gun of horizontal gene transfer.

Nature reviews. Genetics·2023
Same author

microRNAs as systemic regulators of ageing.

Nature reviews. Genetics·2023

Related Experiment Video

Updated: Feb 26, 2026

Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

5.5K

Alternative splicing: A thermometer controlling gene expression

Linda Koch

    Nature Reviews. Genetics
    |July 25, 2017
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
    11:48

    Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

    Published on: October 9, 2014

    13.4K
    Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
    10:06

    Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

    Published on: April 26, 2017

    9.5K

    Related Experiment Videos

    Last Updated: Feb 26, 2026

    Using the E1A Minigene Tool to Study mRNA Splicing Changes
    10:25

    Using the E1A Minigene Tool to Study mRNA Splicing Changes

    Published on: April 22, 2021

    5.5K
    Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
    11:48

    Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

    Published on: October 9, 2014

    13.4K
    Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
    10:06

    Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

    Published on: April 26, 2017

    9.5K