Related Experiment Video
Updated: Feb 26, 2026
07:38
Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics
Published on: May 17, 2019
8.6K
Distinct histopathologic features of radiation-induced chronic sinusitis
Hannah N Kuhar1, Bobby A Tajudeen2, Ashley Heilingoetter1
1Rush Medical College, Rush University Medical Center, Chicago, IL.
International Forum of Allergy & Rhinology
|July 25, 2017
Summary
Radiation therapy can cause chronic rhinosinusitis (CRS) with unique histopathology. Radiation-induced CRS (CRSr) shows increased squamous metaplasia and edema, differing from CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP).
Area of Science:
- Otolaryngology
- Pathology
- Oncology
Background:
- Chronic rhinosinusitis (CRS) frequently develops after radiation therapy to the paranasal sinuses.
- The specific histopathologic features of radiation-induced CRS (CRSr) are not well-defined.
- Understanding CRSr histopathology is crucial for effective disease management.
Purpose of the Study:
- To investigate and characterize the histopathologic features of radiation-induced CRS (CRSr).
- To compare these features with CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP).
Main Methods:
- Analysis of sinus tissue from patients undergoing functional endoscopic sinus surgery (FESS).
- Comparison of histopathology variables, Lund-Mackay scores (LMS), and Sino-Nasal Outcome Test (SNOT-22) scores.
- Patients included those with CRSr, CRSsNP, and CRSwNP.
Main Results:
- CRSr cases showed increased squamous metaplasia and subepithelial edema compared to CRSsNP.
- CRSr cases had fewer eosinophils and less basement membrane thickening compared to CRSwNP.
- CRSr patients had significantly higher Lund-Mackay scores than CRSsNP patients.
Conclusions:
- Radiation-induced CRS exhibits distinct histopathologic features, including increased squamous metaplasia and edema.
- CRSr demonstrates reduced eosinophilia and basement membrane thickening compared to CRSwNP.
- These findings highlight the unique nature of radiation in CRS development and may influence treatment strategies.
Related Concept Videos
01:23Chronic Pharyngitis
13.2K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
13.2K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.9K
01:29Anatomy of Respiratory System I: Upper Respiratory Tract
5.8K
The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
5.8K
01:18Lymphoid Cells and Tissues
3.5K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.5K