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Updated: Feb 26, 2026

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Unexpected Chiro-Thermoresponsive Behavior of Helical Poly(phenylacetylene)s Bearing Elastin-Based Side Chains
Sandra Arias1, Felix Freire1, Marcelo Calderón2
1Centro Singular de Investigación en Química Biolóxica e Materiáis Moleculares (CIQUS), Departamento de Química Orgánica, Universidade de Santiago de Santiago de Compostela, Calle Jenaro de la Fuente, 15782, Santiago de Compostela, Spain.
Abstract:
The thermoresponsive behavior of an elastin-based polymer can be altered by the polymeric macromolecular conformation. Thus, when the elastin basic amino acid sequence VPGVG is used as a pendant group of a poly(phenylacetylene) (PPA) its thermoresponsive behavior in water can be remotely detected through conformational changes on the formed helix. Circular dichroism at different temperatures shows an inversion of the first Cotton effect (450 nm) at 25.8 °C that matches with the cloud point temperature. The elastin-based side-chain poly(phenylacetylene) shows an upper critical solution temperature with low pH and concentration dependency, not expected in elastin-based polymers. It was found that the polymer self-assembles in water into spherical nanoparticles with hydrodynamic diameters of 140 nm at the hydrophobic state.
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