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Ex Vivo Rat Eye Model for Investigating Transport of Next Generation Precision-Polyester Nanosystems
Raghu Ganugula1, Meenakshi Arora1, Majeti N V Ravi Kumar1
1Department of Pharmaceutical Sciences, College of Pharmacy, Texas A&M University , Reynolds Medical Building, TAMU Mailstop 1114, College Station, Texas 77843, United States.
Abstract:
We present for the first time a robust ex vivo rat eye model for investigating the transport of precision-polyester nanosystems (P2Ns) across the blood-retinal barrier, intended for systemic administration. The P2Ns-GA actively transport exploiting transferrin receptors present in the inner retinal barrier and colocalize in ganglion cells. Such delivery approaches have the potential to deliver drugs to posterior segments of the eye, which is still a major challenge in treating posterior ocular disorders.
