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Mother and child characteristics at birth and early age leukemia: a case-cohort population-based study

Rejane de Souza Reis1, Neimar de Paula Silva2, Marceli de Oliveira Santos1

  • 1Instituto Nacional do Câncer (INCA), Coordenação de Prevenção e Vigilância, Divisão de Vigilância e Análise de Situação, Rio de Janeiro, RJ, Brazil.

Jornal De Pediatria
|July 25, 2017
PubMed

Insights

Maternal occupational chemical exposure and birth defects are linked to early-age acute leukemia (EAL) in Brazil. This study identifies key risk factors for childhood leukemia, improving global research databases.

Area of Science:

  • Epidemiology
  • Environmental Health
  • Pediatric Oncology

Background:

  • Population-based cancer registries (PBCR) and live birth information systems (SINASC) in Brazil offer data for investigating early-age acute leukemia (EAL) risk factors.
  • Identifying these factors is crucial for understanding and potentially preventing childhood leukemia.

Purpose of the Study:

  • To identify maternal and birth characteristics associated with EAL in Brazil.
  • To leverage existing population-based data for epidemiological research.

Main Methods:

  • A case-cohort study design was employed using secondary data from PBCR and SINASC.
  • Variables included child's birth characteristics and maternal exposures during pregnancy.
  • Logistic regression models calculated adjusted odds ratios (adjOR) and 95% confidence intervals (CI).

Main Results:

  • Maternal occupational exposure to agricultural, chemical, and petrochemical industries was associated with EAL (adjOR: 2.18, 95% CI: 1.16-4.10).
  • Birth defects were also significantly associated with EAL (adjOR: 3.62, 95% CI: 1.19-11.00).

Conclusions:

  • This study identifies significant risk factors for EAL in Brazil.
  • Findings enhance the understanding of childhood leukemia etiology and contribute to global research efforts.
  • Improved databases and knowledge can support future investigations into leukemia risk factors.
Abstract

Keywords:
Birth characteristicsBirth weightBrasilBrazilCaracterísticas ao nascimentoEarly age leukemiaExposições maternasFatores de riscoLeucemias na InfânciaMaternal characteristicsMaternal occupationPeso ao nascer

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