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Related Concept Videos

Subviral Agents01:29

Subviral Agents

656
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
656

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Related Experiment Video

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Large-scale Production of Recombinant RNAs on a Circular Scaffold Using a Viroid-derived System in Escherichia coli
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Engineering resistance against viroids.

Ricardo Flores1, Beatriz Navarro2, Natalia Kovalskaya3

  • 1Instituto de Biología Molecular y Celular de Plantas (UPV-CSIC), Universidad Politécnica de Valencia, Valencia 46022, Spain.

Current Opinion in Virology
|July 25, 2017
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Summary
This summary is machine-generated.

Viroids are small infectious RNAs that cause plant diseases. This review covers strategies like breeding and RNA interference to control viroid infections and reduce crop losses.

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Area of Science:

  • Plant Pathology
  • Molecular Biology
  • Biotechnology

Background:

  • Viroids are the smallest known infectious agents, consisting of small, single-stranded, circular RNAs without protein-coding genes.
  • Despite their simplicity, viroids cause significant diseases in economically important plants, leading to substantial agricultural losses.

Purpose of the Study:

  • To review current and potential strategies for controlling viroid infections in plants.
  • To elucidate the mechanisms, results, and future prospects of various anti-viroid strategies.

Main Methods:

  • Review of existing literature on viroid control strategies.
  • Analysis of genetic transformation techniques for implementing resistance mechanisms.
  • Examination of RNA-based interference methods.

Main Results:

  • Multiple strategies exist, including breeding resistant cultivars, induced resistance, ribonuclease applications, and RNA interference (RNAi).
  • RNAi approaches, such as hairpin RNAs and artificial small RNAs, show significant potential.
  • Genetic transformation is a key method for implementing many of these control strategies.

Conclusions:

  • A diverse range of strategies, from traditional breeding to advanced RNA-based technologies, are available for viroid management.
  • RNA interference and genetic engineering offer promising avenues for future viroid control.
  • Continued research is essential to fully realize the potential of these strategies in mitigating viroid-induced crop damage.