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[The efficacy and safety of ultrafiltration for patients with heart failure: results from a single-center randomized
1Heart Center of Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi 830000, China.
Insights
Ultrafiltration therapy significantly improves heart failure symptoms, reducing body weight and enhancing exercise capacity. This treatment is proven safe and effective for managing heart failure patients.
Area of Science:
- Cardiology
- Nephrology
- Critical Care Medicine
Background:
- Heart failure (HF) is a complex clinical syndrome.
- Effective management strategies are crucial for improving patient outcomes.
- Ultrafiltration offers a potential therapeutic option for fluid overload in HF.
Purpose of the Study:
- To evaluate the efficacy and safety of ultrafiltration therapy in patients diagnosed with heart failure.
- To compare the effects of ultrafiltration versus standard therapy on key clinical parameters.
Main Methods:
- A randomized controlled trial involving 134 heart failure patients.
- Patients were assigned to either standard therapy (control group) or ultrafiltration therapy.
- Key parameters including body weight, dyspnea score, and 6-minute walking distance were assessed.
Main Results:
- Ultrafiltration significantly reduced body weight and improved dyspnea scores and 6-minute walking distance compared to baseline and the control group.
- No significant differences were observed in safety indicators such as blood pressure, heart rate, and key electrolyte levels between groups.
- The treatment demonstrated a favorable safety profile with no adverse effects on renal function markers (Cr, BUN).
Conclusions:
- Ultrafiltration therapy is a safe and effective treatment for heart failure patients.
- It provides significant clinical benefits in managing fluid overload and improving functional capacity.
- This therapy represents a valuable addition to the management of heart failure.
Abstract:
Objective: To evaluate the efficacy and safety of ultrafiltration in patients with heart failure. Methods: One hundred and thirty four cases of patients with heart failure, who hospitalized in our hospital from June 2010 to June 2016 were enrolled in this study. Random serial number was generated using SPSS 22.0 software, patients were then randomly divided into control group and ultrafiltration group with the proportion of 1∶1 (67 cases in each group). Patients in the control group received standard therapy. Patients in the ultrafiltration group received ultrafiltration therapy for 8 hours. Curative effect was evaluated after 8 hours treatment in the control group and after 12 hours in the ultrafiltration group. Following parameters were compared between the two groups: body weight, dyspnea score and 6 minutes walking distance as well as blood pressure, heart rate, Na(+) , K(+) , Cl(-), pH, HCO(3)(-), Hb, PLT, Cr, BUN levels. Results: (1)Two patients died during run-in process and eventually 132 cases were chosen for final analysis (65 cases in control group and 67 cases in the ultrafiltration group). Gender, age, type of heart failure, dyspnea score, body weight at baseline were similar between the two groups. (2)Post therapy, patients' body weight decreased obviously, while dyspnea score and 6 minutes walking distance increased significantly in the ultrafiltration group compared to baseline(all P<0.05), and the improvement was significantly greater compared to control group(all P<0.05). (3)The safety index comparison of two groups: blood pressure, heart rate, Na(+) , K(+) , Cl(-), pH, HCO(3)(-), Hb, PLT, Cr, and BUN were similar between the two groups at baseline and post therapy. Conclusion: Ultrafiltration therapy is safe and effective to treat patients with heart failure.
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