Jove
Visualize
Contact Us

Related Experiment Videos

Effect of somatostatin on renal function.

J P Vora, D R Owens, R Ryder

    British Medical Journal (Clinical Research Ed.)
    |June 28, 1986
    PubMed
    Summary

    Intravenous somatostatin significantly reduces urinary volume, effective renal plasma flow, and glomerular filtration rate in healthy individuals. This impact on kidney function necessitates careful consideration during somatostatin therapy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    IDF diabetes Atlas: A worldwide review of studies utilizing retinal photography to screen for diabetic retinopathy from 2017 to 2024 inclusive.

    Diabetes research and clinical practice·2025
    Same author

    IDF Diabetes Atlas: A review of studies utilising retinal photography on the global prevalence of diabetes related retinopathy between 2015 and 2018.

    Diabetes research and clinical practice·2019
    Same author

    Detecting autoreactive B cells in the peripheral blood of people with type 1 diabetes using ELISpot.

    Journal of immunological methods·2019
    Same author

    Glucocentric risk factors for macrovascular complications in diabetes: Glucose 'legacy' and 'variability'-what we see, know and try to comprehend.

    Diabetes & metabolism·2019
    Same author

    Effect of structured self-monitoring of blood glucose, with and without additional TeleCare support, on overall glycaemic control in non-insulin treated Type 2 diabetes: the SMBG Study, a 12-month randomized controlled trial.

    Diabetic medicine : a journal of the British Diabetic Association·2019
    Same author

    Clinical relevance of pharmacokinetic and pharmacodynamic profiles of insulin degludec (100, 200 U/mL) and insulin glargine (100, 300 U/mL) - a review of evidence and clinical interpretation.

    Diabetes & metabolism·2018
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Nephrology
    • Endocrinology
    • Pharmacology

    Background:

    • Somatostatin influences splanchnic and portal circulation.
    • The renal effects of somatostatin are not fully elucidated.

    Purpose of the Study:

    • To investigate the impact of intravenous somatostatin on renal function in normal subjects.
    • To quantify changes in urinary volume, renal plasma flow, and glomerular filtration rate.

    Main Methods:

    • A randomized controlled study comparing somatostatin infusion (100 micrograms/h) with saline infusion.
    • Measurement of urinary volume, effective renal plasma flow (ERPF), and glomerular filtration rate (GFR) using isotope clearance techniques (iodine-125 iodohippurate and chromium-51 edetic acid).
    • Clearance periods of 20 minutes were utilized.

    Related Experiment Videos

    Main Results:

    • Somatostatin infusion led to a significant decrease in urinary volume (p < 0.01), ERPF (p < 0.001), and GFR (p < 0.05) after 120 minutes.
    • Control saline infusion showed no significant changes in these renal parameters.
    • Basal values for urinary volume, ERPF, and GFR were 254 ml/20 min, 568 ml/min/1.73 m2, and 110 ml/min/1.73 m2, respectively.

    Conclusions:

    • Intravenous somatostatin administration markedly impairs renal function.
    • Clinicians should be aware of these renal effects when prescribing somatostatin.
    • Further research may explore the mechanisms behind somatostatin-induced renal changes.