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Refining forelimb asymmetry analysis: Correlation with Montoya staircase contralateral function post-stroke.

Moner Ragas1, Devipriyanka Nagarajan1, Adrian M Corbett1

  • 1Neuroscience, Cell Biology & Physiology Department, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH 45435, United States.

Journal of Neuroscience Methods
|July 26, 2017
PubMed
Summary
This summary is machine-generated.

Refining the Forelimb Asymmetry Test by distinguishing fingertip touches as abnormal post-stroke significantly improves its ability to assess motor function deficits. This enhanced method correlates better with other functional tests after stroke.

Keywords:
Contralateral limbFingertipForelimb asymmetryIschemic strokeMontoya staircasePalm

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Area of Science:

  • Neuroscience
  • Animal Behavior
  • Motor Function Assessment

Background:

  • The Forelimb Asymmetry Test (FAT) is a standard method for evaluating motor function in rodents based on exploration behavior.
  • A notable observation is an apparent increase in fingertip touches to the wall by the impaired forelimb after stroke.

Purpose of the Study:

  • To refine the Forelimb Asymmetry Test (FAT) for improved sensitivity in detecting motor deficits post-stroke.
  • To enhance the correlation between the FAT and other established functional assessments.

Main Methods:

  • The study involved counting both palm (normal) and fingertip (abnormal) touches to the wall by each forepaw during exploration.
  • Exploration bouts were analyzed to differentiate fingertip touches associated with transitions from rest to activity.

Main Results:

  • Statistical analysis revealed significant differences in wall-touching patterns pre-stroke versus post-stroke, with a marked increase in fingertip touches.
  • Classifying fingertip touches as abnormal significantly increased the FAT's sensitivity and improved its correlation with contralateral deficits measured by the Montoya Staircase test.
  • Considering all wall touches as normal resulted in reduced sensitivity and a weaker correlation with functional deficits.

Conclusions:

  • This refined Forelimb Asymmetry analysis, by differentiating fingertip touches, offers a more sensitive measure of motor function.
  • The improved FAT demonstrates a better correlation with contralateral motor function assessed by the Montoya Staircase test following stroke.