Magnetic resonance enterography with oral mannitol solution: Diagnostic efficacy and image quality in Crohn disease

Area of Science:

• Gastroenterology
• Radiology
• Medical Imaging

Background:

• Crohn disease (CD) is a chronic inflammatory bowel disease.
• Accurate diagnosis and monitoring of CD are crucial for patient management.
• Magnetic resonance enterography (MRE) is an advanced imaging technique for evaluating the small bowel.

Purpose of the Study:

• To assess the diagnostic efficacy of MRE using oral mannitol solution for Crohn disease.
• To evaluate the image quality of MRE with oral mannitol solution in CD patients.

Main Methods:

• Retrospective analysis of MRE examinations in 153 patients with suspected or confirmed CD.
• Comparison of MRE findings with histopathologic results from surgery or endoscopy.
• Calculation of sensitivity, specificity, and diagnostic efficacy rates.
• Evaluation of MRE image quality on a four-point scale.

Main Results:

• MRE demonstrated high diagnostic performance with 92.5% sensitivity, 93% specificity, and 92.8% overall diagnostic efficacy.
• Excellent image quality (score 1) was achieved in 62% of analyzed small bowel segments.
• Six false-positive and five false-negative findings were noted, with specific differential diagnoses identified.

Conclusions:

• MRE with oral mannitol solution provides excellent image quality for evaluating Crohn disease.
• This imaging modality exhibits high diagnostic efficacy in identifying and assessing CD in patients.