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Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children

Seda Topçu1, Bayram Özhan2, Afra Alkan3

  • 1Ankara University Faculty of Medicine, Department of Pediatrics, Division of Social Pediatrics, Ankara, Turkey.

Journal of Clinical Research in Pediatric Endocrinology
|July 26, 2017
PubMed

Insights

Amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) is linked to growth velocity in children. However, this study found NT-proCNP is not a reliable biomarker for childhood obesity in the Turkish population.

Area of Science:

  • Pediatric Endocrinology
  • Biomarkers
  • Childhood Growth and Obesity

Background:

  • C-type natriuretic peptide (CNP) is an emerging growth marker in children.
  • Previous studies suggest plasma CNP levels may be reduced in obese adolescents, indicating potential as a biomarker.
  • The role of CNP in childhood obesity requires further investigation.

Purpose of the Study:

  • To investigate the relationship between amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) concentration and height velocity in children.
  • To test the hypothesis that CNP is a potential biomarker in childhood obesity within a Turkish population.

Main Methods:

  • A cohort of 317 children (ages 0-18) and their parents provided consent.
  • Physical examinations and anthropometric measurements, including BMI, were conducted.
  • Plasma NT-proCNP concentration was measured using enzyme-linked immunosorbent assay (ELISA) from routine blood samples.

Main Results:

  • Plasma NT-proCNP concentration correlated negatively with age, weight, and height, confirming its association with growth velocity.
  • Gender did not significantly affect age-dependent plasma NT-proCNP concentration before puberty.
  • Contrary to prior reports, overweight/obese children in this Turkish cohort did not show significantly lower plasma NT-proCNP levels compared to normal-weight children.

Conclusions:

  • The study did not find plasma NT-proCNP to be a significantly lower in overweight/obese children compared to normal-weight children in the analyzed Turkish population.
  • It is premature to conclude that CNP is a reliable biomarker for childhood obesity.
  • Further research is needed to clarify the role of CNP in childhood obesity.
Abstract

Keywords:
C-type natriuretic peptideamino-terminal propeptide of C-type natriuretic peptidegrowth biomarker.obesityoverweight

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