Related Experiment Video
Updated: Feb 26, 2026
07:04
Confocal Time Lapse Imaging as an Efficient Method for the Cytocompatibility Evaluation of Dental Composites
Published on: November 9, 2014
14.1K
Genotoxicity Induced by Dental Materials: A Comprehensive Review
Daniel Araki Ribeiro1,2, Veronica Quispe Yujra2, Carolina Foot Gomes DE Moura3
1Department of Biosciences, Federal University of São Paulo, UNIFESP, Sao Paolo, Brazil daribeiro@unifesp.br.
Anticancer Research
|July 26, 2017
Summary
Dental materials can cause genotoxicity, damaging DNA and potentially leading to cancer. This review highlights risks associated with bleaching, restorative, and endodontic dental compounds, informing safer oral healthcare practices.
Area of Science:
- Oral Health
- Toxicology
- Biomaterials Science
Background:
- Genotoxicity, the ability of an agent to damage DNA, is linked to cancer development.
- Assessing genotoxicity of dental materials is crucial for patient and professional safety.
- Understanding these risks aids in preventing oral carcinogenesis.
Purpose of the Study:
- To comprehensively review genotoxicity induced by dental materials.
- To consolidate existing data on the DNA-damaging potential of various dental products.
- To inform regulatory practices for safer oral healthcare.
Main Methods:
- Literature review of published studies on dental material genotoxicity.
- Analysis of data concerning DNA damage from dental bleaching agents.
- Evaluation of genotoxicity data for restorative and endodontic materials.
Main Results:
- All reviewed data indicated some level of genotoxicity from dental materials.
- Dental bleaching agents showed notable genotoxic effects.
- Restorative materials and endodontic compounds also presented evidence of genotoxicity.
Conclusions:
- Dental materials, particularly bleaching agents, restorative compounds, and endodontic materials, exhibit genotoxic potential.
- This evidence is vital for risk assessment in dental practice.
- Findings support the development of safer dental materials and practices to prevent oral cancer.
Related Concept Videos
01:26Toxic Reactions: Overview
2.8K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
2.8K
01:25Mutagenicity and Carcinogenicity
2.0K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
2.0K
01:24Drug Toxicity: Dose-Dependent Reactions
54
Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
54
01:25Bioactivation and Tissue Toxicity
65
Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
65
01:15Teeth
1.9K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
1.9K
01:23Toxicity Testing in Animals
63
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
63