Systematic Therapeutic Drug Monitoring for Linezolid: Variability and Clinical Impact

Linezolid serum trough (C_min) and peak (C_max) levels were determined prospectively in 90 patients. Adequate exposure was defined as a C_min of 2 to 8 mg/liter. Therapy was empirical (73.3%) or targeted (26.7%). Wide interindividual variability in linezolid C_min levels was recorded (0.1 to 25.2 μg/ml). Overall, 65.5% of the patients had out-of-range, 41.1% had subtherapeutic, and 24.4% had supratherapeutic trough levels. We did not find a correlation between abnormal levels and adverse events, in-hospital mortality, or overall poor outcome.