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Raised-Volume Forced Expiratory Flow-Volume Curve in Healthy Taiwanese Infants

Shen-Hao Lai1,2,3, Sui-Ling Liao2,4,3, Tsung-Chieh Yao1,2,3

  • 1Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Scientific Reports
|July 26, 2017
PubMed

Insights

This study establishes reference data for infant lung function in Taiwan using raised-volume rapid thoracoabdominal compression (RVRTC). These findings aid in diagnosing respiratory diseases in Asian infants.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology
  • Biomedical Engineering

Background:

  • Reference data for full forced expiratory flow-volume curves using raised-volume rapid thoracoabdominal compression (RVRTC) are lacking for Asian populations.
  • Accurate reference data are crucial for diagnosing respiratory conditions in infants.

Purpose of the Study:

  • To establish predictive reference equations for Taiwanese infants using RVRTC.
  • To provide equipment-specific reference data for full forced expiration in Asian infants.

Main Methods:

  • Full-term infants underwent RVRTC manoeuvres to obtain full forced expiratory flow-volume curves using Jaeger's system.
  • Tidal breath analysis and passive respiratory mechanics were also measured.
  • Multiple linear regression analyses were used to develop predictive models.

Main Results:

  • 117 RVRTC flow-volume curves were obtained from 97 infants.
  • Most RVRTC parameters positively correlated with body length.
  • RVRTC parameters showed moderate relationships with other infant lung function measures.

Conclusions:

  • This study provides the first equipment-specific reference data for RVRTC manoeuvres in Asian infants.
  • These race-specific reference data can improve the diagnosis of respiratory diseases in infants of Chinese ethnicity.
  • RVRTC parameters are moderately related to other infant lung function parameters.

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