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Kidney function and cognitive decline in an oldest-old Chinese population
Kunhao Bai1,2, Yujing Pan3, Fanghong Lu4
1Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People's Republic of China.
Clinical Interventions in Aging
|July 26, 2017
Summary
Early-stage chronic kidney disease is linked to cognitive decline in very elderly Chinese individuals. This study highlights the importance of kidney function in maintaining cognitive health in older populations.
Area of Science:
- Gerontology
- Nephrology
- Neuroscience
Background:
- Cognitive decline is a growing concern in aging populations.
- Early-stage chronic kidney disease (CKD) is increasingly recognized as a potential risk factor for cognitive impairment.
- However, research on this association in the oldest-old (≥80 years) is limited.
Purpose of the Study:
- To investigate the association between early-stage chronic kidney disease and cognitive decline.
- To explore this relationship in a cohort of Chinese individuals aged 80 years and older.
Main Methods:
- A prospective study followed 284 Chinese participants (≥80 years) with serum creatinine <150 µmol/L for a median of 3.3 years.
- Kidney function was assessed by estimated glomerular filtration rate (eGFR).
- Cognitive function was measured using the Mini-Mental State Examination (MMSE), with cognitive decline defined by a Reliable Change Index of 1.645.
Main Results:
- The study observed 18 cases (7.3%) of incident cognitive decline.
- Participants with an eGFR of 30-59 mL/min/1.73 m² had a 4.03 times higher relative risk of developing cognitive decline compared to those with eGFR ≥60 mL/min/1.73 m².
- This association remained significant after adjusting for potential confounders.
Conclusions:
- Early-stage chronic kidney disease is significantly correlated with cognitive decline in the oldest-old Chinese population.
- These findings underscore the importance of monitoring kidney function in elderly individuals to potentially mitigate cognitive decline.
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