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Focusing on a complete blood cell parameter: mean platelet volume levels may be a predictor of coronary slow flow
Mücahid Yılmaz1, Mustafa Necati Dağlı2, Ökkeş Uku1
1Department of Cardiology, Elazığ Education and Research Hospital.
Insights
Increased mean platelet volume (MPV) is linked to coronary slow flow (CSF). This study found higher MPV levels in CSF patients, suggesting MPV may predict CSF.
Area of Science:
- Cardiology
- Hematology
- Vascular Biology
Background:
- Mean platelet volume (MPV) is associated with atherosclerosis.
- The relationship between MPV and coronary slow flow (CSF) requires further investigation.
Purpose of the Study:
- To compare MPV levels in patients with CSF versus normal coronary anatomy (NCA).
- To determine if MPV can serve as a predictor for CSF.
Main Methods:
- Retrospective analysis of 80 patients (40 with CSF, 40 with NCA) from Elaziğ Education and Research Hospital.
- Coronary angiography was used to diagnose NCA and CSF (thrombolysis in myocardial infarction criteria).
- Laboratory data, including MPV, and anamnesis information were collected and analyzed.
Main Results:
- MPV levels were significantly higher in the CSF group (10.05±1.3) compared to the NCA group (8.6±0.6) (p<0.001).
- An MPV cutoff of >9.05 demonstrated 77.5% sensitivity and 77.5% specificity for predicting CSF (AUC: 0.825, p<0.0001).
- MPV was identified as an independent predictor of CSF (β=-600, p<0.001).
Conclusions:
- MPV levels are elevated in patients with coronary slow flow compared to those with normal coronary anatomy.
- These findings suggest that MPV is a potential predictor for coronary slow flow.
Background:
The relationship between increased mean platelet volume (MPV) and atherosclerosis is well known. In the present study, MPV in patients with coronary slow flow (CSF) and in cases with normal coronary anatomy (NCA) was investigated and compared with the aim of identifying the relationship between CSF and MPV.
Patients And Methods:
We studied 40 patients previously determined via coronary angiography as having NCA and 40 patients with CSF in the coronary blood stream, as identified by thrombolysis in myocardial infarction square. Thus, a total of 80 patients from the Elaziğ Education and Research Hospital (Elaziğ, Turkey) were included in the present study retrospectively and laboratory and anamnesis information was scanned into their files. The relationship between MPV and CSF was studied.
Results:
MPV levels were observed to be significantly higher in the CSF group compared to the NCA group (10.05±1.3 and 8.6±0.6, p<0.001). In receiver operating characteristics analyses, it was determined that an MPV >9.05 measured in CSF patients at application had a predictive specificity of 77.5% and sensitivity of 77.5% for CSF (area under the curve: 0.825, 95% confidence interval [CI]: 0.726-0.924, p<0.0001). It was found that MPV level was an independent predictor of CSF (β=-600, p<0.001, 95% CI: -0.383 to -0.176).
Conclusion:
MPV is increased in patients with CSF when compared to patients with NCA. This finding supports the fact that MPV could be a predictor of CSF.
