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Cardiovascular Disease in Acromegaly

Morali D Sharma1, Anh V Nguyen1, Spandana Brown1

  • 1Houston Methodist Hospital, Houston, Texas.

Methodist Debakey Cardiovascular Journal
|July 26, 2017
PubMed

Insights

Acromegaly causes heart problems like cardiomyopathy due to excess growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Treatment can improve heart function and reduce cardiovascular risks.

Area of Science:

  • Cardiology
  • Endocrinology
  • Internal Medicine

Background:

  • Chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in acromegaly patients.
  • Development of acromegalic cardiomyopathy with specific cardiac features.

Purpose of the Study:

  • To outline the pathophysiology and features of acromegalic cardiomyopathy.
  • To discuss the impact of treatment on cardiac changes and cardiovascular risks.

Main Methods:

  • Review of existing literature on acromegaly and its cardiac manifestations.
  • Analysis of pathophysiologic changes in acromegalic cardiomyopathy.

Main Results:

  • Acromegalic cardiomyopathy characterized by biventricular hypertrophy and diastolic dysfunction.
  • Progression to systolic dysfunction and congestive heart failure in later stages.

Conclusions:

  • Treatment of acromegaly and cardiovascular risk factors can reverse cardiac changes.
  • Intervention decreases the high risk of cardiovascular complications in acromegaly patients.

Keywords:
acromegalyarrhythmiacardiomyopathycoronary artery diseaseheart failurehypertensionvalvular heart disease

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